One class of drugs that has shown promise in treating diseases ranging from lung cancer to COVID-19 are targeted covalent inhibitors (TCIs). These small molecule drugs form covalent bonds with their ...

Chemical bonding is the force of attraction that holds atoms together to form molecules or compounds. There are two primary types of chemical bonds: ionic and covalent bonds. Both these bonds play a ...

Chemical probes that form a covalent bond with a protein target often show enhanced selectivity, potency and utility for biological studies. Despite these advantages, protein-reactive compounds are ...

Naturally occurring peptides and proteins often use dynamic disulfide bonds to impart defined tertiary/quaternary structures for the formation of binding pockets with uniform size and function.

"SOMETIMES IT SEEMS to me that a bond between two atoms has become so real, so tangible, so friendly, that I can almost see it. Then I awake with a little shock, for a chemical bond is not a real ...