What if a cup of coffee could help treat cancer? Researchers at the Texas A&M Health Institute of Biosciences and Technology ...

A new CRISPR-based one-off procedure that lowers "bad" cholesterol has been approved to enter Phase I human trial. If ...

Researchers at The University of Tokyo developed TECHNO, a two-step genome editing strategy that replaces entire mouse loci with human genomic DNA. The method integrates fragments over 200 kbp.

Understanding human gene function in living organisms has long been hampered by fundamental differences between species.

Mice and newts were applied to the one-step Cre-loxP organism creation technology by TAx9. In this study, the researchers succeeded in synthesizing a Cre-loxP integrated vector by placing a short DNA ...

Humanized mouse models are essential for investigating human gene function; however, the complete replacement of mouse genes ...

Scientists at the MRC Laboratory of Medical Sciences (LMS) have discovered a DNA-based “dimmer switch” that regulates the activity of a critical developmental gene, Cdx2. This work could pave the way ...

Why do some tumors spread while others remain localized? The mechanisms governing the metastatic potential of tumor cells ...

Understanding how a potential drug is metabolised in the liver is a critical first step in early-stage drug development - but ...

What if you could flip a genetic switch to silence a gene, then turn it back on with a simple drug? For researchers, gene-switch tools offer that kind of control—and a new system called Cyclone may ...