Research has shown that a mutation in the ATAXIN-1 gene leads to accumulation of Ataxin-1 (ATXN1) protein in brain cells and is the root cause of a rare genetic neurodegenerative disease known as ...

Spinocerebellar ataxia type 1 (SCA1) primarily affects the brainstem, spinocerebellar tracts and cerebellar Purkinje cells. Patients with SCA1 develop progressive ataxia of limb and gait, as well as ...

Research has shown that a mutation in the ATAXIN-1 gene leads to accumulation of Ataxin-1 (ATXN1) protein in brain cells and is the root cause of a rare genetic neurodegenerative disease known as ...

Expansion of an unstable translated CAG repeat located in different disease genes has so far been identified as causing nine dominantly inherited neurodegenerative disorders, the so-called ...

When researchers prescribed mild exercise for mice with a neurodegenerative disorder called spinocerebellar ataxia 1, they did not know what to expect. What they found was the mice that exercised ...

The Orengo Lab studies motor neuron degeneration using single gene mutation models to determine the common underpinnings involved in triggering this degeneration. Spinocerebellar ataxia type 1 (SCA1) ...

A recent study suggests that spinocerebellar ataxia 1 (SCA1), a neurodegenerative disorder of the cerebellum, could affect the functioning of the hippocampus, possibly explaining the mysteriously high ...

The spinocerebellar ataxias (SCAs) are dominantly inherited neurodegenerative disorders characterized by a progressive loss of balance and coordination, and eventually the inability to coordinate ...

Manipulating a novel mechanism that regulates ATXN1 levels reduced ATXN1 and improved some of the symptoms of neurodegenerative disease SCA1 in animal models. Research has shown that a mutation in the ...